Ammonia → HCID 66621425, compound

Participants

Reaction Steps

Methyl 2-(1-azabicyclo[3.2.1]octan-5-yl)benzo[d]oxazole-7-carboxylate (80 mg, 0.28 mmol) was added to ammonia in methanol (15 ml) and the mixture was stirred at room temperature for 3 days. Then the solid was filtered, washed with methanol, the residue solution was concentrated under vacuum. Then the residue was purified by flash column chromatography to give 2-(1-azabicyclo[3.2.1]octan-5-yl)benzo[d]oxazole-7-carboxamide (20.6 mg, yield: 27%) 1H-NMR (400 MHz, CD3OD) δ: 1.18 (s, 1H), 1.63-1.67 (m, 1H), 1.82 (s, 1H), 1.94-1.98 (m, 1H), 2.10-2.15 (m, 2H), 2.23-2.28 (m, 1H), 2.38-2.44 (m, 1H), 2.91-2.93 (m, 2H), 3.12-3.18 (m, 1H), 3.20-3.30 (m, 1H), 7.34-7.37 (t, J=8 Hz, 1H), 7.72-7.77 (m, 2H), LC-MS (m/z): 272 (M+1)+.

Provenance & Evidence