Ethyl Acetate → HCID 23655191, compound

Participants

Reaction Steps

2-(4-(Methoxycarbonyl)phenyl)ethanaminium chloride (3 g, 13.9 mmol) was dissolved in the mixed solution of tetrahydrofuran (30 mL) and water (30 mL), and then benzyl chloroformate (2.37 g, 13.9 mmol) was dropped into it. To the mixture, sodium bicarbonate (2.9 g, 34.7 mmol) was added and the mixture was stirred at room temperature for 1.5 h. Then the mixture was poured into ethyl acetate (50 mL×3) and the organic layer was washed with saturated sodium bicarbonate solution, dried with anhydrous sodium sulfate and condensed to get methyl 4-(2-(benzyloxycarbonylamino)ethyl)benzoate (3.3 g, yield 77%). LC-MS (ESI) m/z: 314 (M+1)+.

Provenance & Evidence