Ammonia → HCID 66621653, compound

Participants

Reaction Steps

Methyl 2-(4-(2-((benzyloxycarbonyl)(methyl)amino)ethyl)phenyl)benzo[d]oxazole-7-carboxylate (150 mg, 0.34 mmol) was added to ammonia in methanol (5 ml) and the mixture was stirred at room temperature for 2 days. Evaporate the solvent to obtain benzyl 4-(7-carbamoylbenzo[d]oxazol-2-yl)phenethyl(methyl)carbamate as a white solid (140 mg, yield 96%). 1H-NMR (400 MHz, DMSO-d6) δ (ppm): 2.84-2.91 (m, 5H), 3.52-3.56 (t, J=7 Hz, 2H), 4.96-5.05 (d, J=36 Hz, 2H), 7.28-7.42 (m, 6H), 7.47-7.51 (t, J=7.8 Hz, 2H), 7.80-7.82 (d, J=7.6 Hz, 1H), 7.85-7.87 (d, J=8 Hz, 2H), 7.94-7.96 (d, J=8 Hz, 1H), 8.18-8.2 (m, 2H); LC-MS (ESI) m/z: 430 (M+1)+.

Provenance & Evidence