HCID 66621653, compound → HCID 44181678, compound

Participants

Reaction Steps

A mixture of benzyl 4-(7-carbamoylbenzo[d]oxazol-2-yl)phenethyl(methyl)carbamate (110 mg, 0.26 mmol), 10% Pd/C (20 mg) in methanol (20 ml) was stirred at room temperature over 1 atm hydrogen for 3 h. Then the mixture solution was filtered and the filtrate was evaporated under reduced pressure. The residue was purified by prep-HPLC to give 2-(4-(2-(methylamino)ethyl)phenyl)benzo[d]oxazole-7-carboxamide (20 mg, yield 26%). 1H-NMR (400 MHz, CD3OD) δ (ppm): 2.45 (s, 3H), 2.91-2.94 (m, 4H), 7.47-7.52 (m, 3 H), 7.88-7.92 (t, J=7.2 Hz, 2H), 8.26-8.28 (d, J=8.4 Hz, 2H). LC-MS (ESI) m/z: 296 (M+1)+.

Provenance & Evidence