Propanal → HCID 44181558, compound

Participants

Reaction Steps

A solution of 2-(4-(piperidin-4-yl)phenyl)benzo[d]oxazole-7-carboxamide (200 mg, 0.62 mmol), 10% Pd/C (50 mg) and propanal (0.8 mL, 1.86 mmol) in methanol (20 mL) was purged with hydrogen at room temperature overnight. The solution was filtered and the filtrate was concentrated, the residue was purified by prep-HPLC to give 2-(4-(1-propylpiperidin-4-yl)phenyl)benzo[d]oxazole-7-carboxamide (53 mg, yield 23%). 1H-NMR (400 MHz, CD3OD) δ (ppm): 1.01 (s, 3H), 1.79 (s, 2H), 2.03-2.09 (m, 4H), 3.31-3.34 (m, 2H), 3.67 (s, 2H), 7.30-7.41 (m, 3H), 7.83 (s, 2H), 8.16 (s, 2H); LC-MS (ESI) m/z: 364 (M+1)+.

Provenance & Evidence