Diisopropylethylamine → HCID 66624271, compound

Participants

Reaction Conditions

Reaction Steps

A microwave reaction vessel was charged with N-{2-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}-N,N′,N′-trimethylsulfamide (Method 30, 51.9 mg, 0.150 mmol), (S)-1-(5-fluoropyrimidin-2-yl)ethanamine hydrochloride (Method 7, 53.3 mg, 0.301 mmol), and DIPEA (0.079 ml, 0.449 mmol). Anhydrous n-BuOH (1 ml) was added, and the tube was sealed and heated in a microwave reactor at 180° C. for 4 hours. The reaction mixture was purified by silica gel chromatography (by ISCO Combiflash with gradient EtOAc and hexanes) to afford the title compound as a white solid (47.4 mg, 70%). LC-MS, 451 (M+1). 1H NMR (DMSO-d6, 400 MHz, 80° C.) δ 11.61 (s, 1H), 8.95 (s, 1H), 8.77 (s, 2H), 5.84-6.89 (m, 3H), 5.17-5.23 (m, 1H), 3.17 (s, 3H), 2.74 (s, 6H), 2.18 (s, 3H), 1.54 (d, 3H).

Provenance & Evidence