Diisopropylethylamine → HCID 178461874, compound

Participants

Reaction Conditions

Reaction Steps

A microwave reaction vessel was charged with N3-(2-chloro-5-fluoropyrimidin-4-yl)-N5,N5-dimethyl-1H-pyrazole-3,5-diamine (Method 35, 50 mg, 0.2 mmol), (S)-1-(5-fluoropyrimidin-2-yl)ethanamine hydrochloride (Method 7, 50 mg, 0.23 mmol), and DIPEA (0.15 ml, 0.86 mmol) in n-BuOH (1 ml) was heated in a microwave reactor at 160° C. for 2 hours. Solvent was removed. The residue was purified by silica gel chromatography (by ISCO Combiflash with gradient 0-5% Methanol in methylene chloride with 1% NH4OH) to afford the title compound as a white solid (49 mg, 67%). 1H NMR (CD3OD, 400 MHz) δ 8.77 (s, 2H), 8.23 (s, 1H), 5.32 (br, 1H), 3.92 (q, 1H), 3.13 (s, 6H), 1.71 (d, 3H); m/z 362

Provenance & Evidence