Diisopropylethylamine → HCID 178493047, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-1-(5-fluoropyrimidin-2-yl)ethanamine hydrochloride (Method 7, 139 mg), N-(5-methoxy-1H-pyrazol-3-yl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4-amine (Method 45, 265 mg) and DIPEA (0.35 ml) in n-BuOH (5.0 ml) was heated at 90° C. for 6 hours. The solvent was removed under reduced pressure and the residue was purified by Gilson (10-50% MeCN/H2O, 15 minutes) to give the titled compound as solid (16.3 mg). 1H NMR δ 12.11 (s, 1H) 10.47 (s, 1H) 8.86 (s, 2H) 8.29 (s, 1H) 6.27 (s, 1H) 5.30 (s, 1H) 5.13-5.25 (m, 1H) 3.77 (s, 3H) 1.51 (d, 3H); m/z 399.

Provenance & Evidence