HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415429Generated: October 29, 2026
Pyrimidine, 2,4-dichloro-5-methyl- → 2-chloro-5-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
https://huagongshe.com/reaction/415429
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrimidine, 2,4-dichloro-5-methyl- | HCID 74508 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-chloro-5-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 50993643 | — |
Reaction Steps
To a solution of 2,4-dichloro-5-methylpyrimidine (1.25 g, 7.8 mmol) in EtOH (30 ml) was added 5-methyl-1H-pyrazol-3-ylamine (756 mg, 7.8 mmol) and DIPEA (2.8 mL). The mixture was heated at 70° C. overnight. LC/MS showed the completion of the reaction. The title compound was obtained by filtration under vacuum as a white solid (700 mg). m/z 224.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088784B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-9a3a65070e894422a8fe9441f8082c36 |
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| Source note | uspto-grants-2012_01 |
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