Diisopropylethylamine → HCID 86624841, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(2,6-dichloropyrimidin-4-yl)-N,N′,N′-trimethylsulfamide (Method 27, 1.72 g, 6.05 mmol) in n-BuOH (6 ml) was added 5-methyl-1H-pyrazol-3-amine (0.605 g, 6.05 mmol) and DIPEA (1.6 mL, 9.09 mmol). The mixture was heated at 70° C. overnight. The reaction mixture was filtered; the solid was washed by MeOH three times to give pure white solid. (0.205 g, 9.7% yield). LC-MS, 346 (M+1). NMR (DMSO-d6, 400 MHz, 80° C.) δ 11.89 (s, 1H), 9.82 (s, 1H), 7.22 (s, 1H), 5.97 (s, 1H), 3.32 (s, 3H), 2.87 (s, 6H), 2.21 (s, 3H).

Provenance & Evidence