Triethylamine → 5-Bromo-2-chloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-2,4-dichloropyrimidine (1.20 g, 5.26 mmol) in THF (10 ml) at room temperature was added 5-methoxy-1H-pyrazol-3-amine (594 mg, 5.26 mmol) and triethylamine (685 mg, 6.3 mmol) and the reaction mixture was stirred at 40° C. overnight. The suspension was filtered and washed with water and dried to give the desired product as a white solid. MS: 305 (M+1).

Provenance & Evidence