HCID 86633711, compound → HCID 86633712, compound

Participants

Reaction Steps

2-Chloro-3-nitro-N-(pyridin-3-ylmethyl)quinolin-4-amine (13.0 g, 41.0 mmol), 5% platinum on carbon (1.3 g), and acetonitrile (60 mL) were added to a hydrogenation vessel and placed under hydrogen pressure (50 psi, 3.4×105 Pa) overnight. The mixture was filtered through a layer of CELITE filter agent, and the filter cake was washed with acetonitrile and methanol. The filtrate was concentrated under reduced pressure to provide 10.25 g of 2-chloro-N4-(pyridin-3-ylmethyl)quinoline-3,4-diamine, which was used without purification.

Provenance & Evidence