Hydrochloric Acid → HCID 44466336, compound

Participants

Reaction Steps

In a 15-mL round-bottom flask ethyl 2-(3,4-dichlorobenzyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylate (0.46 mmol) was dissolved in a mixture of THF (2 mL) and MeOH (2 mL). Lithium hydroxide monohydrate (0.93 mmol) was dissolved in water (2 mL) and added to the reaction flask dropwise. The reaction mixture was stirred at room temperature for 6 hours, and then acidified with 1N aqueous HCl. The resulting mixture containing precipitate was poured into a separatory funnel and dichloromethane added until all precipitate dissolved (200 mL). The resulting solution was washed with water (50 mL) and dried over MgSO4. Concentration yielded 2-(3,4-dichlorobenzyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid as light-yellow precipitate. The final compound is more soluble in chloroform than dichloromethane.

Provenance & Evidence