Hexylamine → HCID 44466084, compound

Participants

Reaction Steps

In a 15-mL round-bottom flask 2-(3,4-dichlorobenzyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (0.065 mmol) was dissolved in dichloromethane (2.4 mL). HOBT (0.01 mmol), EDC hydrochloride (0.13 mmol), triethylamine (0.13 mmol), and n-hexylamine (0.13 mmol) were added sequentially to the reaction flask and stirred overnight. Extracted with 1N aqueous HCl and dichloromethane. Organic layer concentrated and residue chromatographed on silica gel using 2% MeOH in dichloromethane as eluent. Product 2-(3,4-dichlorobenzyl)-3-oxo-N-hexyl-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide was obtained as white solid.

Provenance & Evidence