tert-Butanol → HCID 44466334, compound

Participants

Reaction Conditions

Reaction Steps

In a 2 mL Smith Process™ vial 2-(3,4-dichlorobenzyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (0.142 mmol) was dissolved in t-butanol (2 mL) and triethylamine (0.17 mmol) was added, followed by DPPA (0.17 mmol). The reaction mixture was heated at 160° C. for 30 minutes in Emrys Optimizer™ microwave reactor. The reaction mixture was concentrated and partitioned between water and chloroform. Organic layer was dried over MgSO4, concentrated, and chromatographed on silica gel using 5% MeOH in CH2Cl2 as eluent. The product tert-butyl 2-(3,4-dichlorobenzyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridin-6-ylcarbamate was isolated as pink oil.

Provenance & Evidence