反应详情

In step (1) of Reaction Scheme I, a 4-chloroquinolin-3-amine or 4-chloro[1,5]naphthyridin-3-amine of Formula XX is reacted with an acid halide of Formula Hal-Z—CH2—C(O)—Hal to provide an N-(4-chloroquinolin-3-yl)amide or N-(4-chloro[1,5]naphthyridin-3-yl)amide of Formula XXI. The reaction can be carried out by heating a solution of a compound of Formula XX and the acid halide in a suitable solvent such as 1,2-dichloroethane. Some acid chlorides of Formula Hal-Z—CH2—C(O)—Hal are commercially available; others can be prepared using conventional synthetic methods. Some 4-chloroquinolin-3-amines and 4-chloro[1,5]naphthyridin-3-amines of Formula XX are known. Others can be prepared using conventional synthetic methods; for example, by reduction of known 4-chloro-3-nitroquinolines and 4-chloro-3-nitro[1,5]naphthyridines.

1. customIn step (1) of Reaction Scheme I