HCID 66620405, compound → HCID 66620408, compound

HRID 415500Notes

Reaction equation

HRID 415500 reaction equation
[CH:1]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:2]=1[C:3]1[N:13]3[N:14]=[CH:15][CH:16]=[CH:17][C:12]3=[N:11][C:4]=1[CH:5]=[N:6]2.[N:18]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:19]=1[C:20]1[N:30]3[N:31]=[CH:32][CH:33]=[CH:34][C:29]3=[N:28][C:21]=1[CH:22]=[N:23]2>>[CH:1]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:2]=1[C:3]1[N:13]3[N:14]=[CH:15][CH:16]=[CH:17][C:12]3=[N:11][C:4]=1[C:5]([NH2:18])=[N:6]2.[N:18]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:19]=1[C:20]1[N:30]3[N:31]=[CH:32][CH:33]=[CH:34][C:29]3=[N:28][C:21]=1[C:22]([NH2:6])=[N:23]2

Participants

4

Reactant 2

HCID 66620405HCID 66620405, compoundHCID 66620932HCID 66620932, compound

Product 2

HCID 66620408HCID 66620408, compoundHCID 66620603HCID 66620603, compound

Procedure

In steps (6) and (7) of Reaction Scheme III, a pyridazino[1′,6′:1,2]imidazo[4,5-c]quinoline or pyridazino[1′,6′:1,2]imidazo[4,5-c][1,5]naphthyridine of Formula XLIV is oxidized and then aminated to provide a pyridazino[1′,6′:1,2]imidazo[4,5-c]quinolin-6-amine or pyridazino[1′,6′:1,2]imidazo[4,5-c][1,5]naphthyridin-6-amine of Formula XLV, a subgenus of Formula I. The steps can be carried out using the methods described in steps (5) and (6) of Reaction Scheme I.

Sources & evidence

ORD record
ord-f7065e47419749519ed16173fe304be5
Source dataset
uspto-grants-2012_01
Patent number
US08088788B2

Reaction notes

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