HCID 178419901, compound → HCID 178507385, compound

HRID 415502Notes

Reaction equation

HRID 415502 reaction equation
[NH:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.[NH:14]1[C:26]2[C:25]3[N:24]=[CH:23][CH:22]=[CH:21][C:20]=3[N:19]=[CH:18][C:17]=2[N:16]=[CH:15]1>>[NH:1]1[C:13]2[C:12]3[C:7](=[C:8]([NH2:14])[CH:9]=[CH:10][CH:11]=3)[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.[NH:14]1[C:26]2[C:25]3[C:20](=[C:21]([NH2:1])[CH:22]=[CH:23][N:24]=3)[N:19]=[CH:18][C:17]=2[N:16]=[CH:15]1

Participants

4

Reactant 2

HCID 178419901HCID 178419901, compoundHCID 1784207351h-Imidazo[4,5-c][1,5]naphthyridine

Product 2

HCID 178507385HCID 178507385, compoundHCID 178507867HCID 178507867, compound

Procedure

In steps (8) and (9) of Reaction Scheme IV, a 1H-imidazo[4,5-c]quinoline or 1H-imidazo[4,5-c][1,5]naphthyridine of Formula LII is oxidized and then aminated to provide a 1H-imidazo[4,5-c]quinolin-6-amine or 1H-imidazo[4,5-c][1,5]naphthyridin-6-amine of Formula LIII, a subgenus of Formula I. The steps can be carried out using the methods described in steps (5) and (6) of Reaction Scheme I.

Sources & evidence

ORD record
ord-77ff5af5b50e4e45a6ab99433bd0af22
Source dataset
uspto-grants-2012_01
Patent number
US08088788B2

Reaction notes

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