Cyanogen Bromide → 1H-imidazo[4,5-c]quinoline-1,2-diamine

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Reaction Steps

In step (1) of Reaction Scheme VIII, a tert-butyl N′-(3-aminoquinolin-4-yl)hydrazinecarboxylate or a tert-butyl N′-(3-amino[1,5]naphthyridin-4-yl)hydrazinecarboxylate of Formula XXXIX is reacted with cyanogen bromide to provide a 1H-imidazo[4,5-c]quinoline-1,2-diamine or 1H-imidazo[4,5-c][1,5]naphthyridine-1,2-diamine of Formula LXVI. The reaction can be carried out by adding cyanogen bromide to a solution of compound of Formula XXXIX in a suitable solvent such as ethanol and heating.

Provenance & Evidence