Methanol → HCID 66620426, compound

Participants

Reaction Steps

A pressure bottle was charged with platinum on carbon (5%, 0.70 g) followed by tert-butyl 2,2-dimethyl-3-[(3-nitroquinolin-4-yl)amino]propylcarbamate dissolved in 250 mL of toluene. The reaction mixture was shaken under H2 at 48 PSI (3.3×105 Pa). The next day, the reaction mixture was carefully charged with 25 mL of MeOH and filtered through a pad of CELITE filter agent. The pad was rinsed with 1:1 CH2Cl2/methanol. The solvent was removed under reduced pressure to give tert-butyl 3-[(3-aminoquinolin-4-yl)amino]-2,2-dimethylpropylcarbamate as a light yellow solid.

Provenance & Evidence