1,1'-Thiocarbonyldiimidazole → HCID 86633742, compound

Participants

Reaction Steps

tert-Butyl 3-[(3-aminoquinolin-4-yl)amino]-2,2-dimethylpropylcarbamate (7.16 g, 20.8 mmol) was suspended in 200 mL of CH2Cl2 and treated with 1,1′-thiocarbonyldiimidazole (4.07 g, 22.9 mmol) under an atmosphere of N2. After about 2 hours a precipitate had formed. It was isolated by filtration and dried under vacuum to afford tert-butyl 2,2-dimethyl-3-(2-thioxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate (7.78 g) as a white solid.

Provenance & Evidence