Dichloromethane methanol → (10S)-10-methyl-9,10-dihydro-8H-imidazo[1',2':1,2]imidazo[4,5-c]quinoline

Participants

Reaction Steps

The title compound was prepared from tert-butyl (2S)-2-[(3-nitroquinolin-4-yl)amino]propylcarbamate according to the methods of Parts C through G of Example 22 with the following modifications. Part C was carried out in acetonitrile as the solvent. Part D required chromatography (SiO2, 0-6% methanol/CH2Cl2). Following chromatographic purification (SiO2, 20-40% CMA/CHCl3) in Part G, the title compound, (10S)-10-methyl-9,10-dihydro-8H-imidazo[1′,2′:1,2]imidazo[4,5-c]quinoline (2.14 g), was obtained as an off white foam.

Provenance & Evidence