Methyl iodide → HCID 66620306, compound

Participants

Reaction Steps

Iodomethane (0.89 mL, 14 mmol) was added to a suspension of tert-butyl 3-(7-bromo-2-thioxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate (4 g, 9 mmol) in deionized water (25 mL), ethanol (25 mL), and ammonium hydroxide (5 mL), and the reaction was stirred for two hours at room temperature and then diluted with chloroform and water. The aqueous layer was separated and extracted four times with chloroform. The combined organic fractions were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was dried under high vacuum to provide 2.7 g of tert-butyl 3-(7-bromo-2-(methylthio)-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate.

Provenance & Evidence