Acetic Acid → HCID 66620252, compound

Participants

Reaction Steps

A solution of potassium permanganate (1.9 g, 12 mmol) in deionized water (90 mL) was added to a solution of tert-butyl 3-(7-bromo-2-(methylthio)-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate (2.7 g, 6 mmol) in glacial acetic acid (35 mL), and the reaction was stirred at room temperature overnight. The reaction was diluted with water and treated with sodium bisulfite. The aqueous layer was separated and extracted three times with chloroform. The combined organic fractions were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide 2.3 g of tert-butyl 3-(7-bromo-2-(methylsulfonyl)-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate.

Provenance & Evidence