Water → HCID 66620899, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, potassium tert-butoxide (6 mL of a 1 M solution in THF) was added to a solution of tert-butyl 3-(7-bromo-2-(methylsulfonyl)-1H-imidazo[4,5-c]quinolin-1-yl)propylcarbamate (2.3 g, 4.8 mmol) in THF (50 mL). The reaction was stirred overnight at room temperature, and an analysis by LC/MS indicated the presence of starting material. Additional potassium tert-butoxide solution (4 mL) was added, and the reaction was stirred for an additional 30 minutes at room temperature. The reaction was poured into water. A solid was present and was washed with water and dried for three days in a vacuum oven to provide 0.95 g of tert-butyl 3-bromo-10,11-dihydropyrimido[1′,2′:1,2]imidazo[4,5-c]quinoline-8(9H)-carboxylate.

Provenance & Evidence