m-Chloroperbenzoic acid → HCID 66620274, compound

Participants

Reaction Steps

MCPBA (800 mg of approximately 60% pure material) was added to a solution of tert-butyl 3-bromo-10,11-dihydropyrimido[1′,2′:1,2]imidazo[4,5-c]quinoline-8(9H)-carboxylate (940 mg, 2.3 mmol) in chloroform (50 mL). The reaction was stirred for one hour at room temperature, and an analysis by LC/MS indicated the presence of starting material. Additional MCPBA (540 mg) was added, and the reaction was stirred for an additional 30 minutes and then diluted with water and chloroform. The aqueous layer was separated and extracted twice with chloroform. The combined organic fractions were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide 0.97 g of tert-butyl 3-bromo-5-oxido-10,11-dihydropyrimido[1′,2′:1,2]imidazo[4,5-c]quinoline-8(9H)-carboxylate.

Provenance & Evidence