Trifluoroacetic acid → HCID 136356810, compound

Participants

Reaction Steps

Trifluoroacetic acid (4 mL) was added to a solution of tert-butyl 6-amino-3-bromo-10,11-dihydropyrimido[1′,2′:1,2]imidazo[4,5-c]quinoline-8(9H)-carboxylate (0.16 g) in dichloromethane (0.400 mL), and the resulting solution was stirred for two hours at room temperature. An analysis by LC/MS indicated the presence of starting material, and additional trifluoroacetic acid was added. The reaction was stirred for an additional four hours, concentrated under reduced pressure, and purified according to the method of Examples 8 through 12 to provide 3-bromo-8,9,10,11-tetrahydropyrimido[1′,2′:1,2]imidazo[4,5-c]quinolin-6-amine trifluoroacetate, observed accurate mass 318.0367 (M+H).

Provenance & Evidence