Hydrochloric Acid → HCID 59402655, compound

Participants

Reaction Steps

A solution of K2CO3 (500 mg, 3.62 mmol, 5.75 equiv.) in water (5 ml) was added to a solution of 3-[3-(aminocarbonyl)phenoxy]methylphenyl acetate (180 mg, 0.63 mmol, 1 equiv.) and the mixture was stirred at r.t., under N2, for 3 h; The mixture was acidified with 10% HCl solution to pH 1, and was extracted with EtOAc (2×30 ml). The combined organic extracts were washed with water (30 ml), dried (Na2SO4) and evaporated to dryness under reduced pressure, to give a clear oil residue which, after trituration with Et2O, solidified to a white solid (70 mg, 46% yield). Mp 122-123° C., HPLC-MS (method 1): m/z 244 [M+H]+. Rt=2.92 min.

Provenance & Evidence