HCID 66619734, compound → HCID 59402678, compound

Participants

Reaction Steps

4-[3-(Aminocarbonyl)-2,4-difluorophenoxy]-2-butenoic acid (100 mg, 0.32 mmol) was stirred with 5% Rh/C (5 mg) in butanol (5 ml) under H2, at r.t. for 21 h. The reaction mixture was filtered through a pad of celite and rinsed with CH2Cl2 (3×5 ml). The filtrate was evaporated to dryness, under reduced pressure, to give 88 mg of the desired product, yield 87%, mp 53-55° C. HPLC-MS (method 1): m/z 316 [M+H]+, Rt=3.49 min.

Provenance & Evidence