HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(1-Benzothiophen-5-ylmethoxy)-2,6-difluorobenzenecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Benzothiophen-5-ylmethanol | HCID 2795446 | — |
| Reactant | 5-(Chloromethyl)benzo[b]thiophene | HCID 23261722 | — |
| Reactant | 2,6-Difluoro-3-hydroxybenzamide | HCID 45120136 | — |
| Product | 3-(1-Benzothiophen-5-ylmethoxy)-2,6-difluorobenzenecarboxamide | HCID 59403010 | 10% |
Reaction Steps
Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide according to Method B, scheme 2. The required building block, 5-(chloromethyl)-1-benzothiophene, was synthesised by chlorination of commercially available 1-benzothiophen-5-ylmethanol with thionyl chloride. Yield 10%, mp 146-148° C., HPLC-MS (method 1): m/z 320 [M+H]+, Rt=3.95 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088791B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-6ce73ba1af514328a8c66906ff448974 |
| Source note | uspto-grants-2012_01 |