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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415615Generated: October 25, 2026

2,6-Difluoro-3-hydroxybenzamide → 3-[(4-Ethyl-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamide

https://huagongshe.com/reaction/415615

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Difluoro-3-hydroxybenzamideHCID 45120136—
Reactant2-(Chloromethyl)-4-ethyl-1,3-benzothiazoleHCID 53440947—
Product3-[(4-Ethyl-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamideHCID 5940268017%

Reaction Steps

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide and 2-(chloromethyl)-4-ethyl-1,3-benzothiazole according to Method B, scheme 2. Yield 17%, mp 184-186° C., HPLC-MS (method 1): m/z 349 [M+H]+, Rt=4.16 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088791B2
Source datasetuspto-grants-2012_01
ORD IDord-1c991b926e8a420a9727860e6b2fc143
Source noteuspto-grants-2012_01