HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 3-Azido proline methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | 3-Hydroxyproline methyl ester | HCID 18634729 | — |
| Product | 3-Azido proline methyl ester | HCID 59162825 | — |
Reaction Steps
Reaction of 3-hydroxyproline methyl ester with DIAD, triphenylphosphine and diphenylphosphoryl azide provides the desired 3-azido proline methyl ester. Transformation is typically carried out at low temperatures, e.g., 0° C., and after the addition, the reaction is allowed to warm to ambient temperature, e.g., about 25° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088804B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-171954cafe044fccb2ee8ae78a8863e7 |
| Source note | uspto-grants-2012_01 |