O-(Tetrahydropyran-2-yl)hydroxylamine → HCID 86638432, compound

Participants

Reaction Steps

(2S,4R)-Benzyl 4-hydroxy-4-(methoxymethyl)-2-(tetrahydro-2H-pyran-2-yloxycarbamoyl)pyrrolidine-1-carboxylate is prepared from (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxy-4-(methoxymethyl)pyrrolidine-2-carboxylic acid and O-(tetrahydro-2H-pyran-2-yl)hydroxylamine following Method G (yield=59%). 1H NMR (300 MHz, CHCl3) δ 7.57-7.18 (m, 5H), 5.33-5.07 (m, 2H), 4.64-4.45 (m, 1H), 4.09-3.21 (m, 7H), 2.44-1.98 (m, 3H); ESI(+) calcd. for C15H18NO6 (308.11). Found 308.0

Provenance & Evidence