Hydrochloric Acid → HCID 178434565, compound

Participants

Reaction Conditions

Reaction Steps

4-(4-cyano-tetrahydro-pyran-4-yl)-benzoic acid methyl ester (300 mg, 1.22 mmol) was suspended in water and then 4N NaOH was added and heated at 110° C. for 15 minutes. To this solution 2N HCl was added to precipitate the product. The solid was filtered out and used for next step without further purification. 4-(4-carbamoyl-tetrahydro-pyran-4-yl)-benzoic acid (200 mg, 0.80 mmol) was dissolved in DMF and then DMA-acetal in excess was added. The mixture was heated at 50° C. for 20 minutes. The reaction mixture was evaporated and used for next step without further purification. 4-[4-(1-dimethylamino-ethylidenecarbamoyl)-tetrahydro-pyran-4-yl]-benzoic acid methyl ester (50 mg, 0.150 mmol) and hydrazine hydrate (0.015 mL, 2 eq) were dissolved in AcOH and heated at 50° C. for 20 minutes. The reaction mixture was evaporated and used for next step without further purification. Hydrolysis HATU coupling, and amine de-protection was carried out following the same procedures from Example 64 using (3-amino-4′-fluoro-biphenyl-4-yl)-carbamic acid tert-butyl ester instead of (2-amino-4-thiophen-2-yl-phenyl)-carbamic acid tert-butyl ester. MS found for C27H25FN4O3 as (M+H)+ 473.21. 1H NMR (400 MHz, dmso-d6): δ: 13.31 (s, 1H), 9.55 (s, 1H), 7.82 (d, J=7.6 Hz, 2H), 7.50 (dd, J=8.8, 5.2 Hz, 2H), 7.41 (s, 1H), 7.35 (d, J=8.4 Hz, 2H), 7.20 (dd, J=8.0-2.4 Hz, 1H), 7.14 (t, J=8.8 Hz, 2H), 6.77 (d, J=6.77 Hz, 1H), 5.00 (s, 2H), 3.73-3.71 (m, 2H), 3.37-3.31 (m, 2H), 2.58-2.55 (m, 2H), 2.24 (s, 3H), 2.06-2.03 (m, 2H).

Provenance & Evidence