2-Ethylacrylic acid → N-(4-Cyano-3-trifluoromethyl-phenyl)-2-ethyl-acrylamide

HRID 415961Notes

Reaction equation

HRID 415961 reaction equation
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11])#[N:2].[CH2:14]([C:16](=[CH2:20])[C:17](O)=[O:18])[CH3:15]>>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH:7][C:17](=[O:18])[C:16]([CH2:14][CH3:15])=[CH2:20])=[CH:5][C:4]=1[C:10]([F:11])([F:12])[F:13])#[N:2]

Participants

3

Reactant 2

HCID 191662-Ethylacrylic acidHCID 5221704-Amino-2-(trifluoromethyl)benzonitrile

Product 1

HCID 16756178N-(4-Cyano-3-trifluoromethyl-phenyl)-2-ethyl-acrylamide

Procedure

Following the procedure described in Example 1, starting from 4-cyano-3-trifluoromethyl-aniline and 2-ethyl-acrylic acid, the title compound was prepared as a yellow solid.

Sources & evidence

ORD record
ord-77586c44165a4b62bc9116db0534f602
Source dataset
uspto-grants-2012_01
Patent number
US08088811B2

Reaction notes

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