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N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide → 3-Amino-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methyl-propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide | HCID 10149314 | — |
| 反応物 | Ammonia methanol | HCID 21705897 | — |
| 生成物 | 3-Amino-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methyl-propionamide | HCID 66620251 | — |
反応手順
2-Methyl-oxirane-2-carboxylic acid (4-cyano-3-trifluoromethyl-phenyl)-amide (1.0 g, 3.48 mmoL) was dissolved in 7N NH3/MeOH solution (10 mL) at room temperature. The reaction mixture was stirred overnight and the solvent was removed to yield the title compound as pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088811B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-9596a80a7b8b4adb9a1190940e467ea3 |
| 出典メモ | uspto-grants-2012_01 |