HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,10-Phenanthroline → HCID 16756855, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,10-Phenanthroline | HCID 1318 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Amino-5-iodo-2-(trifluoromethyl)benzonitrile | HCID 25067377 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 16756855 | HCID 16756855 | — |
Reaction Steps
4-Amino-5-iodo-2-trifluoromethyl-benzonitrile (312 mg, 1.0 mmol), CuI (I) (20 mg, 0.1 mmol), Cs2CO3 (652 mg, 2.0 mmol) and 1,10-phenanthroline (36 mg, 0.2 mmol) were mixed in methanol (20 ml). The reaction mixture was refluxed overnight and then the solvent was removed under vacuum. Upon separation on silica gel (100% CH2Cl2), the tile compound was obtained as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088811B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ad98132a116f41bbae38c06284e1d17d |
| Source note | uspto-grants-2012_01 |