HCID 178418361, compound → HCID 178455342, compound

Participants

Reaction Steps

Add a solution of 3-(4-benzyloxy-2,6-dichloro-benzyl)-cis-1-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one (8.5 g 15.1 mmol) in 25 mL tetrahydrofuran to 0.5 g Pearlman's catalyst and hydrogenate the resulting mixture under a balloon of hydrogen gas 2 hr. Filter through Celite® and concentrate to get a solid. Purify by silica gel chromatography using hexanes/ethyl acetate to recover 4.4 g (61%) of product.

Provenance & Evidence