HCID 178418361, compound → HCID 178496578, compound

Participants

Reaction Steps

Stir (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-trans-1-(4-methoxy-cyclohexyl)-pyrrolidin-2-one (2.59 g, 5.61 mmol) and palladium hydroxide (20% on carbon) (0.300 g, 10% by weight) in 100 ml of ethyl acetate. Bubble hydrogen gas through the solution while stirring at room temperature for 5 minutes. Stir the mixture under the hydrogen gas atmosphere for 5 hours. Filter through Celite® and concentrate under vacuum to recover 2.08 g of the title compound (99%). MS (m/z): 372 (M+).

Provenance & Evidence