Potassium Carbonate → HCID 178497511, compound

Participants

Reaction Conditions

Reaction Steps

Mix trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-trans-1-(4-methoxy-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester (2.134 g, 4.24 mmol), (4-methoxycarbonylphenyl)boronic acid (0.926 g, 5.09 mmol), tetrakis(triphenylphosphine)palladium(0) (0.490 g, 0.42 mmol) and 6.36 ml of 2M solution of K2CO3 in DME (10 mL). Stir for 12 hours at 80° C. Quench the reaction with water and extract with ethyl acetate. Wash the extract with brine and dry over magnesium sulfate. Purify by flash chromatography to recover 1.68 g (81%) of the title compound: MS (m/z): 490 (M+).

Provenance & Evidence