Hydrogen Peroxide → HCID 57741478, compound

Participants

Reaction Steps

Add potassium carbonate (83 mg, 0.6 mmol) and hydrogen peroxide (30% in water, 0.5 mL) to a solution of Preparation 13 (3′,5′-dichloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-3-fluoro-biphenyl-4-carbonitrile) (88 mg, 0.2 mmol) in DMSO (3 mL). Stir the reaction at room temperature for 12 h. Partition the mixture between ethyl acetate (20 mL) and water (20 mL). Separate the organic layer, wash three times with water (15 mL each) then brine (15 mL). After drying the organic layer over sodium sulfate, filter and concentrate under vacuum. Purify the residue by silica gel chromatography with 1:1 ethyl acetate/hexane to afford the title compound: MS (m/z): 463 (M+).

Provenance & Evidence