m-Chloroperbenzoic acid → HCID 87078300, compound

Participants

Reaction Steps

Dissolve racemic 3′,5′-dichloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide (0.097 g, 0.183 mmol) in dichloromethane (5 mL) under argon atmosphere. Add 3-chloroperoxybenzoic acid (0.045 g, 0.200 mmol) and stir at room temperature for 1 hour. Concentrate under reduced pressure and purify via flash chromatography by eluding with gradient (100%) dichloromethane to 25% methanol/75% dichloromethane to obtain 0.086 g (87%) of a white solid: MS (m/z): 546 (M+).

Provenance & Evidence