Trifluoroacetic acid → HCID 66621762, compound

Participants

Reaction Steps

Dissolve chiral 5-[3′,5′-dichloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carbonyl]-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (0.119 g, 0.19 mmol) in dichloromethane (3 mL), treat with trifluoroacetic acid (1 mL) and stir for 1 hour at room temperature. Remove the solvent under vacuum, dissolve the residue in ethyl acetate and wash with saturated aqueous sodium bicarbonate then water. Dry the organic layer with sodium sulfate, concentrate under vacuum and purify the crude product by silica gel chromatography using a gradient of 0 to 10% methanol in dichloromethane to afford 100 mg (100%) of the title compound: MS (m/z): 526 (M+).

Provenance & Evidence