Neopentyl glycol → HCID 58294023, compound

Participants

Reaction Steps

A solution of 3′-bromo-2′-(2-bromoethoxy)-5′-chloroacetophenone (Reference compound No. 4-1, 4.4 g, 10 mmol), neopentylglycol (1.2 g, 1.2 mmol) and p-toluenesulfonic acid monohydrate (0.22 g, 12 mmol) in anhydrous toluene (50 mL) was refluxed overnight. After cooling, ethyl acetate (50 mL) and saturated aqueous sodium hydrogen carbonate solution (100 mL) were added to the reaction mixture and the whole was partitioned. The organic layer was washed with brine (50 mL) and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography to give the title reference compound (2.8 g) as a pale yellow oil (Yield 63%).

Provenance & Evidence