4-(Trifluoromethyl)phenylboronic acid → 1-(4-(4-(Trifluoromethyl)phenyl)thien-2-yl)ethanone

HRID 416035Notes

Reaction equation

HRID 416035 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:10][C:11]([F:22])([F:21])[C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 27352371-(4-Bromo-2-thienyl)ethan-1-one

Product 1

HCID 591803041-(4-(4-(Trifluoromethyl)phenyl)thien-2-yl)ethanone

Procedure

1-(4-(4-(Trifluoromethyl)phenyl)thien-2-yl)ethanone is prepared from (4-bromothien-2-yl)ethanone and 4-trifluoromethylphenylboronic acid according to general procedure A.

Sources & evidence

ORD record
ord-331a1ab0226d478ab8490f30d1a02dea
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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