4-(Trifluoromethyl)phenylboronic acid → 5-Acetyl-2-[4-(trifluoromethyl)phenyl]furan

HRID 416039Notes

Reaction equation

HRID 416039 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:15]1[O:19][C:18]([C:20](=[O:22])[CH3:21])=[CH:17][CH:16]=1>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:15]2[O:19][C:18]([C:20](=[O:22])[CH3:21])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 110305851-(5-Bromofuran-2-yl)ethan-1-one

Product 1

HCID 591803155-Acetyl-2-[4-(trifluoromethyl)phenyl]furan

Procedure

1-(5-(4-(Trifluoromethyl)phenyl)fur-2-yl)ethanone is prepared from 4-trifluoromethylbenzeneboronic acid and 5-bromo-2-acetylfuran according to general procedure A.

Sources & evidence

ORD record
ord-09f34556f48b4f6e9cdb90b1f2b70c40
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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