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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 416046Generated: November 1, 2026

3-Fluoro-4-hydroxybenzaldehyde → 3-(3-Fluoro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one

https://huagongshe.com/reaction/416046

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-hydroxybenzaldehydeHCID 587250—
Reactant1-(5-(4-(Trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-oneHCID 4191494—
Product3-(3-Fluoro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-oneHCID 66623699—

Reaction Steps

3-(3-Fluoro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one is prepared from 1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)ethanone and 3-fluoro-4-hydroxybenzaldehyde according to general procedure B. The residue is crystallized from acetonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088819B2
Source datasetuspto-grants-2012_01
ORD IDord-488ca3a95a53440996fd47a0af8c7d77
Source noteuspto-grants-2012_01