Sodium Hydroxide → HCID 25059216, compound

HRID 416072Notes

Reaction equation

[Cl:1][C:2]1[C:20]([Cl:21])=[C:19]([CH2:22][CH2:23][C:24](=[O:40])[C:25]2[S:26][C:27]([C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=3)=[CH:28][CH:29]=2)[CH:18]=[CH:17][C:3]=1[O:4][CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]CC)=[O:7].[OH-].[Na+]>>[Cl:1][C:2]1[C:20]([Cl:21])=[C:19]([CH2:22][CH2:23][C:24](=[O:40])[C:25]2[S:26][C:27]([C:30]3[CH:31]=[CH:32][C:33]([C:36]([F:37])([F:38])[F:39])=[CH:34][CH:35]=3)=[CH:28][CH:29]=2)[CH:18]=[CH:17][C:3]=1[O:4][CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 59180338HCID 59180338, compound

Product 1

HCID 25059216HCID 25059216, compound

Procedure

2-(2,3-Dichloro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)-2-phenylacetic acid is prepared from ethyl 2-(2,3-dichloro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl) phenoxy)-2-phenylacetate according to general procedure F using 20 equivalents of 2N sodium hydroxide solution.

Sources & evidence

ORD record: ord-a54d0a9a222c42e2b3ccadc1177d8546
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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