tert-Butyl 2-bromo-2-methylpropionate → HCID 25059470, compound

HRID 416074Notes

Reaction equation

HRID 416074 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([C:13]1[S:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:16][CH:17]=1)=[O:12].Br[C:29]([CH3:38])([CH3:37])[C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11](=[O:12])[C:13]1[S:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:20][CH:19]=2)=[CH:16][CH:17]=1)[O:8][C:29]([CH3:38])([CH3:37])[C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31]

Participants

3

Reactant 2

HCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 59180309HCID 59180309, compound

Product 1

HCID 25059470HCID 25059470, compound

Procedure

Tert-butyl 2-(3-chloro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate is prepared from 3-(2-chloro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propan-1-one and tert-butyl bromoisobutyrate according to general procedure D.

Sources & evidence

ORD record
ord-e1cd83dd93f147679e5a18f6f119a840
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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