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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 416075Generated: October 29, 2026

tert-Butyl 2-bromo-2-methylpropionate → Tert-butyl 2-(2-fluoro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate

https://huagongshe.com/reaction/416075

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 2-bromo-2-methylpropionateHCID 90290—
Reactant3-(3-Fluoro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propan-1-oneHCID 59180339—
ProductTert-butyl 2-(2-fluoro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoateHCID 25059472—

Reaction Steps

Tert-butyl 2-(2-fluoro-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate is prepared from 3-(3-fluoro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propan-1-one and tert-butyl bromoisobutyrate according to general procedure D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088819B2
Source datasetuspto-grants-2012_01
ORD IDord-c7d92f95451340dfa531077c730a2762
Source noteuspto-grants-2012_01